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Semax
ACTH(4‑10) Heptapeptide Analog
Also referenced as: Semax · ACTH(4-10) Pro-Gly-Pro · Met-Glu-His-Phe-Pro-Gly-Pro · MEHFPGP
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Lab Results
| Test | Result | Status |
|---|---|---|
| Purity | – | Pending |
| Quantitation (Avg) | – | Pending |
| Heavy Metals (ICP-MS) | – | Pending |
| Endotoxin (USP <85>) | – | Pending |
| Sterility (PCR) | – | Pending |
| Multi Vial Tested | – | Pending |
Made in cGMP- and ISO-certified facilities vetted by our established North American supply partner. Virtus tracks the factory batch number on every lot and catalogues it against independent lab testing, with a final Certificate of Analysis from ILS Laboratories. We pay more to source this way because we hold the highest standard for the product and for you.
Curated research on Semax
Medvedeva EV (2014). The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis BMC Genomics.
PMID: 24661604 →Eremin KO (2005). Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents Neurochem Res.
PMID: 16362768 →Sudarkina OY (2021). Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion Int J Mol Sci.
PMID: 34201112 →Tabbì G (2015). Semax, an ACTH4-10 peptide analog with high affinity for copper(II) ion and protective ability against metal induced cell toxicity J Inorg Biochem.
PMID: 25310602 →
About Semax
A synthetic heptapeptide derived from the ACTH(4-10) fragment, extended at the C-terminus with a Pro-Gly-Pro sequence that slows enzymatic breakdown. Semax is investigated in preclinical research for its role in neurotrophic signaling, cognitive-function models, and neuroprotection at the cellular level.
First developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax has been examined in published research as a regulator of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, with studied effects on attention, memory-related pathways, and cellular response to ischemic stress in research models.
Also Referenced As
Semax · ACTH(4-10) Pro-Gly-Pro · Met-Glu-His-Phe-Pro-Gly-Pro · MEHFPGP
Specifications
- Scientific Name
- Met-Glu-His-Phe-Pro-Gly-Pro (ACTH 4-10 Analog)
- CAS Number
- 80714-61-0
- Molecular Formula
- C₃₇H₅₁N₉O₁₀S
- Molecular Weight
- 813.9 g/mol
- Physical Form
- Lyophilized powder
- Purity
- Coming Soon
- Batch Number
- TBD
- Storage
- −20°C, protected from light, avoid repeated freeze-thaw cycles
Storage & Handling
Lyophilized peptides remain stable for 12–24 months when stored properly. Follow standard laboratory protocols for handling.
Storage
Store lyophilized peptide at −20°C in a standard laboratory freezer, protected from light, moisture, and heat. Avoid repeated freeze-thaw cycles.
Shelf Life
Lyophilized form remains stable for 12–24 months at −20°C in the original sealed vial. Always reference the batch-specific COA for verified shelf-life data.
Mechanism & Research Background
Semax is a synthetic heptapeptide with the sequence Met-Glu-His-Phe-Pro-Gly-Pro, based on the 4-10 fragment of adrenocorticotropic hormone (ACTH) with a C-terminal Pro-Gly-Pro tripeptide added to resist enzymatic degradation. Unlike native ACTH fragments, Semax lacks hormonal (adrenal-stimulating) activity and has been studied in research literature for its neurotropic and neuroprotective properties.
In preclinical research models, Semax has been examined for its modulation of the brain-derived neurotrophic factor (BDNF) / TrkB signaling system and nerve growth factor (NGF) expression, pathways central to neuronal survival and plasticity research. Published work has characterized changes in the expression of genes related to neurotrophic support, the dopaminergic and serotonergic systems, and vascular and inflammatory response in cellular and animal research models.
Studied effects in research literature include modulation of cognitive-performance endpoints (attention, learning, and memory-related tasks) and cellular response in models of cerebral ischemia and oxidative stress. Semax remains a research-stage molecule under active investigation; products supplied by Virtus Peptides are intended exclusively for in-vitro laboratory research and are not for human or animal use.
Frequently Researched Questions
What is Semax?
Semax is a synthetic heptapeptide derived from the ACTH(4-10) fragment of adrenocorticotropic hormone, extended at the C-terminus with a Pro-Gly-Pro sequence that resists enzymatic breakdown. First developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, it has accumulated peer-reviewed preclinical research on neurotrophic and neuroprotective signaling. Virtus Peptides supplies Semax as a lyophilized powder strictly for in-vitro laboratory research.
What is the difference between Semax and ACTH?
Semax is based on the 4-10 fragment of adrenocorticotropic hormone (ACTH), but unlike the parent hormone it lacks the adrenal-stimulating (corticotropic) activity. The added C-terminal Pro-Gly-Pro tripeptide slows enzymatic degradation and shifts the molecule's studied activity toward neurotropic and neuroprotective pathways in research models rather than hormonal signaling.
What is Semax's molecular weight?
Semax has a molecular weight of approximately 813.9 g/mol with the molecular formula C₃₇H₅₁N₉O₁₀S. Its amino-acid sequence is Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP).
What research pathways have been studied with Semax?
Published preclinical research has examined Semax in relation to brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression, gene- and protein-expression changes in models of cerebral ischemia, and modulation of the dopaminergic and serotonergic systems. Genome-wide transcriptional studies have characterized its effects on genes tied to neurotrophic support and to vascular and immune response.
What testing does Virtus run on Semax?
Every batch of Virtus Semax is independently tested by ILS Laboratories (ISO/IEC 17025 accredited) across the full QC panel: purity and quantitation by HPLC, heavy metals by ICP-MS, bacterial endotoxin, and sterility. Quantitation and identity are confirmed across five vials per batch for conformity. The full Certificate of Analysis is published in our COA database before any vial ships.
What is the recommended storage temperature for Semax?
Lyophilized Semax should be stored at −20°C, protected from light, in the original sealed vial. Repeated freeze-thaw cycles should be avoided. When stored correctly, lyophilized peptides typically maintain stability for 12–24 months.
