MOT-C
Mitochondrial‑Derived Metabolic Peptide
Also referenced as: MOTS-c · Mitochondrial Open Reading Frame Of The 12S rRNA-c · MT-RNR1 Encoded Peptide · Mitochondrial-Derived Peptide
TestingAwaiting Testing
≥99% Purity
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Certificate Of Analysis
| Test | Result | Status |
|---|---|---|
| Identity & Purity (Avg, HPLC + MS) | — | Pending |
| Net Peptide Weight (Avg) | — | Pending |
| Heavy Metals (ICP-MS) | — | Pending |
| Endotoxins (LAL Assay) | — | Pending |
| Sterility (DNA Microarray) | — | Pending |
Made in cGMP- and ISO-certified facilities our supply chain has vetted in person, then independently multi-lab tested by Virtus with a final Certificate of Analysis from ILS Laboratories. We pay more to source this way because we hold the highest standard for the product and for you.
View the full Certificate of Analysis →Curated research on MOT-C
Lee C (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance Cell Metab.
PMID: 25738459 →Reynolds JC (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis Nat Commun.
PMID: 34470889 →
About MOT-C
A 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of mitochondrial DNA. MOT-C is investigated in preclinical research for its role in metabolic regulation, insulin sensitivity, glucose homeostasis, and AMPK-dependent signaling at the cellular level.
First characterized by Lee et al. (Cell Metabolism, 2015), MOT-C represents a class of mitochondrial peptides that signal between mitochondria and the nucleus. Published research has examined its role as an exercise-induced regulator of metabolic homeostasis and physical capacity, with downstream effects on the AMPK / folate-methionine cycle.
Also Referenced As
MOTS-c · Mitochondrial Open Reading Frame Of The 12S rRNA-c · MT-RNR1 Encoded Peptide · Mitochondrial-Derived Peptide
Specifications
- Scientific Name
- MOTS-c: Mitochondrial Open Reading Frame Of The 12S rRNA-c
- CAS Number
- 1627580-64-6
- Molecular Formula
- C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight
- 2,174.9 g/mol
- Physical Form
- Lyophilized powder
- Purity
- Coming Soon
- Batch Number
- TBD
- Storage
- −20°C, protected from light, avoid repeated freeze-thaw cycles
Storage & Handling
Lyophilized peptides remain stable for 12–24 months when stored properly. Follow standard laboratory protocols for handling.
Storage
Store lyophilized peptide at −20°C in a standard laboratory freezer, protected from light, moisture, and heat. Avoid repeated freeze-thaw cycles.
Shelf Life
Lyophilized form remains stable for 12–24 months at −20°C in the original sealed vial. Always reference the batch-specific COA for verified shelf-life data.
Mechanism & Research Background
MOT-C is a 16-amino-acid peptide with the sequence MRWQEMGYIFYPRKLR, encoded by the MT-RNR1 gene within the 12S rRNA region of mitochondrial DNA. It is one of a growing class of mitochondrial-derived peptides (MDPs) that act as retrograde signals from the mitochondrion to the rest of the cell. Published research describes MOT-C as regulating metabolic homeostasis through AMPK activation and the folate-methionine cycle.
In preclinical research models, MOT-C has been shown to translocate to the nucleus in response to metabolic stress, where it regulates the expression of antioxidant and metabolic response genes. Cellular signaling work has examined its effects on glucose uptake, fatty acid oxidation, and insulin sensitivity across multiple tissue types, particularly skeletal muscle and adipose tissue.
Effects in research models include modulation of skeletal muscle glucose handling, hepatic lipid metabolism, and adipose tissue function. Phase 0/preclinical literature has examined endpoints relevant to obesity, type 2 diabetes, age-related metabolic decline, and exercise capacity. The peptide remains a research-stage molecule under active investigation; products supplied by Virtus Peptides are intended exclusively for in-vitro laboratory research and are not for human or animal use.
